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    Amendment: SEC Form SCHEDULE 13D/A filed by Zentalis Pharmaceuticals Inc.

    12/15/25 5:16:18 PM ET
    $ZNTL
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $ZNTL alert in real time by email



    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549


    SCHEDULE 13D

    Under the Securities Exchange Act of 1934

    (Amendment No. 2)


    Zentalis Pharmaceuticals, Inc.

    (Name of Issuer)


    Common Stock, par value $0.001 per share

    (Title of Class of Securities)


    98943L107

    (CUSIP Number)


    Gregory A. Brown
    Matrix Capital Management Company LP, 1000 Winter Street, Suite 4500
    Waltham, MA, 02451
    (603) 956-9145


    Ele Klein & Adriana Schwartz
    McDermott Will & Schulte LLP, 919 Third Avenue
    New York, NY, 10022
    212-756-2000

    (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)
    12/15/2025

    (Date of Event Which Requires Filing of This Statement)


    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. Checkbox not checked

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).






    SCHEDULE 13D

    CUSIP No.
    98943L107


    1 Name of reporting person

    Matrix Capital Management Company, LP
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    OO
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    6,459,973.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    6,459,973.00
    11Aggregate amount beneficially owned by each reporting person

    6,459,973.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    9.98 %
    14Type of Reporting Person (See Instructions)

    IA, PN



    SCHEDULE 13D

    CUSIP No.
    98943L107


    1 Name of reporting person

    David E. Goel
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    OO
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    6,459,973.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    6,459,973.00
    11Aggregate amount beneficially owned by each reporting person

    6,459,973.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    9.98 %
    14Type of Reporting Person (See Instructions)

    IN, HC



    SCHEDULE 13D

    Item 1.Security and Issuer
    (a)Title of Class of Securities:

    Common Stock, par value $0.001 per share
    (b)Name of Issuer:

    Zentalis Pharmaceuticals, Inc.
    (c)Address of Issuer's Principal Executive Offices:

    10275 SCIENCE CENTER DRIVE, SUITE 200, SAN DIEGO, CALIFORNIA , 92121.
    Item 1 Comment:
    The following constitutes Amendment No. 2 ("Amendment No. 2") to the Schedule 13D filed by the undersigned on June 3, 2022 (the "Original Schedule 13D"), as amended by Amendment No. 1 to the Original Schedule 13D filed by the undersigned with the Securities and Exchange Commission on June 20, 2023 ("Amendment No. 1" and the Original Schedule 13D as amended by Amendment No. 1, the "Schedule 13D"). This Amendment No. 2 amends and restates Items 4 and 5(a)-(c). Capitalized terms used herein and not otherwise defined in this Amendment No. 2 have the meanings set forth in the Schedule 13D.
    Item 4.Purpose of Transaction
     
    On December 15, 2025, Karan Takhar, a Senior Managing Director of the Investment Manager, resigned from the board of directors of the Issuer.
    Item 5.Interest in Securities of the Issuer
    (a)
    See rows (11) and (13) of the cover pages to this Schedule 13D for the aggregate number of shares of Common Stock and percentages of the shares of Common Stock beneficially owned by each Reporting Person. The percentages used in this Schedule 13D are calculated based upon 64,750,779 shares of Common Stock outstanding as of December 15, 2025, which is the difference obtained by subtracting (i) 7,500,000 shares of Common Stock sold to the Issuer in the Repurchase (as defined below) from (ii) the 72,250,779 shares of Common Stock outstanding as of November 1, 2025, as reported in the Issuer's Quarterly Report on Form 10-Q for the quarterly period ended September 30, 2025, filed with the SEC on November 10, 2025.
    (b)
    See rows (7) through (10) of the cover pages to this Schedule 13D for the number of shares of Common Stock as to which each Reporting Person has the sole or shared power to vote or direct the vote and sole or shared power to dispose or to direct the disposition.
    (c)
    On December 15, 2025, the Matrix Fund agreed to sell and the Issuer agreed to repurchase 7,500,000 shares of Common Stock from the Matrix Fund at a price of $1.33 per share (the "Repurchase"). The Repurchase closed on December 15, 2025. Except for the Repurchase, no transactions in the shares of Common Stock have been effected by the Reporting Persons during the past sixty (60) days.

        SIGNATURE 
     
    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     
    Matrix Capital Management Company, LP
     
    Signature:/s/ Gregory A. Brown
    Name/Title:Gregory A. Brown, General Counsel, Chief Compliance Officer
    Date:12/15/2025
     
    David E. Goel
     
    Signature:/s/ David E. Goel
    Name/Title:David E. Goel, Individually
    Date:12/15/2025
    Get the next $ZNTL alert in real time by email

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