JP Morgan initiated coverage on Upstream Bio with a new price target
$UPB
Biotechnology: Pharmaceutical Preparations
Health Care
JP Morgan initiated coverage of Upstream Bio with a rating of Overweight and set a new price target of $38.00
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| Date | Price Target | Rating | Analyst |
|---|---|---|---|
| 12/18/2025 | $51.00 | Outperform | Mizuho |
| 11/18/2025 | $40.00 | Outperform | Evercore ISI |
| 10/14/2025 | $47.00 | Buy | Truist |
| 11/5/2024 | $75.00 | Overweight | Piper Sandler |
| 11/5/2024 | $38.00 | Overweight | JP Morgan |
| 11/5/2024 | Outperform | William Blair | |
| 11/5/2024 | Buy | TD Cowen |
4 - Upstream Bio, Inc. (0002022626) (Issuer)
4 - Upstream Bio, Inc. (0002022626) (Issuer)
4 - Upstream Bio, Inc. (0002022626) (Issuer)
– Verekitug provided statistically significant and clinically meaningful reductions in annualized asthma exacerbation rate (AAER) with 100 mg q12 and 400 mg q24 week dosing – – Verekitug also delivered clinically meaningful improvements in lung function (FEV1) and exhaled nitric oxide (FeNO) with both dose regimens – – Verekitug was generally well tolerated, with a safety profile consistent with prior studies – – Over 90% of eligible patients have rolled over to the Phase 2 VALOUR long-term extension study – – Upstream Bio to advance verekitug into Phase 3 trials in severe asthma and CRSwNP following planned regulatory interactions – – Management will host a live webcast today at 8:00
WALTHAM, Mass., Feb. 10, 2026 (GLOBE NEWSWIRE) -- Upstream Bio, Inc. (NASDAQ:UPB), a clinical-stage company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders, today announced it will report top-line results from the Phase 2 VALIANT trial of verekitug, the only known antagonist currently in clinical development that targets and inhibits the thymic stromal lymphopoietin (TSLP) receptor, on Wednesday, February 11, 2026 at 8:00 a.m. ET. The VALIANT trial (NCT06196879) is a Phase 2 global, randomized, double-blind, placebo-controlled, dose-ranging, parallel group clinical trial that evaluated the safety and efficacy of verekitug for up to 60
WALTHAM, Mass., Jan. 05, 2026 (GLOBE NEWSWIRE) -- Upstream Bio, Inc. (NASDAQ:UPB), a clinical-stage company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders, today announced that Rand Sutherland, MD, Chief Executive Officer of Upstream Bio, will be presenting at the 44th Annual J.P. Morgan Healthcare Conference on Monday, January 12, 2026, at 2:15 p.m. PT. A live webcast of the presentation will be available under the Events tab on the Investors section of Upstream Bio's website on the day of the event. A replay will be available on the Company's website following the presentation. About Upstream BioUpstream Bio is a clinical-stage bi
Mizuho initiated coverage of Upstream Bio with a rating of Outperform and set a new price target of $51.00
Evercore ISI initiated coverage of Upstream Bio with a rating of Outperform and set a new price target of $40.00
Truist initiated coverage of Upstream Bio with a rating of Buy and set a new price target of $47.00
4 - Upstream Bio, Inc. (0002022626) (Issuer)
4 - Upstream Bio, Inc. (0002022626) (Issuer)
4 - Upstream Bio, Inc. (0002022626) (Issuer)
8-K - Upstream Bio, Inc. (0002022626) (Filer)
8-K - Upstream Bio, Inc. (0002022626) (Filer)
SCHEDULE 13G/A - Upstream Bio, Inc. (0002022626) (Subject)
– In this 24-week study, VIBRANT met its primary endpoint, with verekitug dosed every 12 weeks leading to a statistically significant and clinically meaningful reduction from baseline in placebo-adjusted endoscopic nasal polyp score (NPS) of -1.8 (p<0.0001) – – Significant and clinically meaningful improvements were observed in key secondary endpoints, including -0.8 (p=0.0003) reduction in nasal congestion score and 76% (p=0.03) reduction in need for surgery or systemic corticosteroids – – No serious adverse events (SAEs) observed; generally well tolerated safety profile consistent with previous studies – – Observed clinical effect on endoscopic NPS in this Phase 2 trial suggests verekit
WALTHAM, Mass., Sept. 01, 2025 (GLOBE NEWSWIRE) -- Upstream Bio, Inc. (NASDAQ:UPB), a clinical-stage company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders, today announced it will report top-line data from the Phase 2 VIBRANT trial of verekitug, the only known clinical-stage monoclonal antibody targeting the receptor for thymic stromal lymphopoietin (TSLP), on Tuesday, September 2, 2025. The VIBRANT trial (NCT06164704) was a Phase 2 global, randomized, placebo-controlled, parallel group clinical trial designed to assess the efficacy and safety of verekitug in adults with CRSwNP. Participants received either 100 mg of verekitug or pl
WALTHAM, Mass., May 20, 2025 (GLOBE NEWSWIRE) -- Upstream Bio, Inc. (NASDAQ:UPB), a clinical-stage company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders, today announced the appointment of Stacy Price, MS, PMP, as Chief Technology Officer. Ms. Price brings over 25 years of experience in technical operations, manufacturing, and product development in the biotechnology industry, across a variety of drug modalities. In this role, Ms. Price will oversee the expansion of technical operations and product development in support of Upstream Bio's global development of verekitug, with a focus on chemistry, manufacturing, and controls (CMC) pr
WALTHAM, Mass., Dec. 17, 2024 (GLOBE NEWSWIRE) -- Upstream Bio, Inc. (NASDAQ:UPB), a clinical-stage company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders, today announced that the Company has appointed Allison Ambrose, J.D. as General Counsel. Ms. Ambrose is a senior legal leader with more than 15 years of experience providing counsel on a wide range of matters including corporate governance, securities law and compliance, and capital markets and corporate development transactions. Ms. Ambrose will oversee all aspects of Upstream's legal function and join the Company's executive leadership team. "I am thrilled to welcome Allison to
SC 13G - Upstream Bio, Inc. (0002022626) (Subject)
SC 13D - Upstream Bio, Inc. (0002022626) (Subject)
SC 13G - Upstream Bio, Inc. (0002022626) (Subject)